Watson Talks a lot about ROMA

SO what is ROMA? Jonathan Sebat at Cold Spring Hrbor describes his research interest s here ... He says:

Large-scale differences in gene copy number, known as copy number polymorphisms (CNPs), are a significant source of human genetic variation. In contrast to DNA sequence variants such as SNPs and microsatellite repeats, CNPs have not been well characterized.....

...We hypothesize that submicroscopic alterations in gene dosage are underlying causes of diseases such as autism, schizophrenia, and Parkinson’s disease. We are currently investigating chromosomal variation in disease using a method for high-resolution analysis of DNA copy number called Representational Oligonucleotide Microarray Analysis (ROMA)

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So what are:
alterations in gene dosage

Representational Oligonucleotide Microarray Analysis

So there's a relevant paper on ROMA here [Representational Oligonucleotide Microarray Analysis: A High-Resolution Method to Detect Genome Copy Number Variation
Robert Lucito, John Healy, Joan Alexander, Andrew Reiner, Diane Esposito, Maoyen Chi, Linda Rodgers, Amy Brady, Jonathan Sebat, Jennifer Troge, Joseph A. West, Seth Rostan, Ken C.Q. Nguyen, Scott Powers, Kenneth Q. Ye, Adam Olshen, Ennapadam Venkatraman, Larry Norton,and Michael Wigler}